Ontology highlight
ABSTRACT:
SUBMITTER: Woodhams LG
PROVIDER: S-EPMC10515162 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Woodhams Louis G LG Guo Jingxuan J Schuftan David D Boyle John J JJ Pryse Kenneth M KM Elson Elliot L EL Huebsch Nathaniel N Genin Guy M GM
Proceedings of the National Academy of Sciences of the United States of America 20230911 38
Fluorescent reporters of cardiac electrophysiology provide valuable information on heart cell and tissue function. However, motion artifacts caused by cardiac muscle contraction interfere with accurate measurement of fluorescence signals. Although drugs such as blebbistatin can be applied to stop cardiac tissue from contracting by uncoupling calcium-contraction, their usage prevents the study of excitation-contraction coupling and, as we show, impacts cellular structure. We therefore developed a ...[more]