Unknown

Dataset Information

0

Simplicity: web-based visualization and analysis of high-throughput cancer cell line screens.


ABSTRACT: High-throughput drug screens are a powerful tool for cancer drug development. However, the results of such screens are often made available only as raw data, which is intractable for researchers without informatic skills, or as highly processed summary statistics, which can lack essential information for translating screening results into clinically meaningful discoveries. To improve the usability of these datasets, we developed Simplicity, a robust and user-friendly web interface for visualizing, exploring, and summarizing raw and processed data from high-throughput drug screens. Importantly, Simplicity allows for easy recalculation of summary statistics at user-defined drug concentrations. This allows Simplicity's outputs to be used with methods that rely on statistics being calculated at clinically relevant doses. Simplicity can be freely accessed at https://oncotherapyinformatics.org/simplicity/.

SUBMITTER: Ling AL 

PROVIDER: S-EPMC10515753 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Simplicity: web-based visualization and analysis of high-throughput cancer cell line screens.

Ling Alexander L AL   Zhang Weijie W   Lee Adam A   Xia Yunong Y   Su Mei-Chi MC   Gruener Robert F RF   Jena Sampreeti S   Huang Yingbo Y   Pareek Siddhika S   Shan Yuting Y   Huang R Stephanie RS  

bioRxiv : the preprint server for biology 20230912


High-throughput drug screens are a powerful tool for cancer drug development. However, the results of such screens are often made available only as raw data, which is intractable for researchers without informatic skills, or as highly processed summary statistics, which can lack essential information for translating screening results into clinically meaningful discoveries. To improve the usability of these datasets, we developed Simplicity, a robust and user-friendly web interface for visualizin  ...[more]

Similar Datasets

| S-EPMC10906814 | biostudies-literature
| S-EPMC5870698 | biostudies-literature
| S-EPMC2639430 | biostudies-literature
| S-EPMC7001883 | biostudies-literature
| S-EPMC7322916 | biostudies-literature
| S-EPMC6625089 | biostudies-literature
| S-EPMC5797032 | biostudies-literature
| S-EPMC5528509 | biostudies-literature
| S-EPMC3374590 | biostudies-literature
| S-EPMC3691752 | biostudies-literature