Ontology highlight
ABSTRACT:
SUBMITTER: Sanganna Gari RR
PROVIDER: S-EPMC10516966 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Sanganna Gari Raghavendar R RR Tagiltsev Grigory G Pumroy Ruth A RA Jiang Yining Y Blackledge Martin M Moiseenkova-Bell Vera Y VY Scheuring Simon S
Communications biology 20230922 1
Transient receptor potential (TRP) ion channels are gated by diverse intra- and extracellular stimuli leading to cation inflow (Na<sup>+</sup>, Ca<sup>2+</sup>) regulating many cellular processes and initiating organismic somatosensation. Structures of most TRP channels have been solved. However, structural and sequence analysis showed that ~30% of the TRP channel sequences, mainly the N- and C-termini, are intrinsically disordered regions (IDRs). Unfortunately, very little is known about IDR 's ...[more]