Ontology highlight
ABSTRACT:
SUBMITTER: Chakraborty P
PROVIDER: S-EPMC10517010 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Chakraborty Pijush P Rivière Gwladys G Hebestreit Alina A de Opakua Alain Ibáñez AI Vorberg Ina M IM Andreas Loren B LB Zweckstetter Markus M
Nature communications 20230922 1
Pathogenic aggregation of the protein tau is a hallmark of Alzheimer's disease and several other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures. The molecular processes that determine isoform-specific deposition of tau are however enigmatic. Here we show that acetylation of tau discriminates its isoform-specific aggregation. We reveal that acetylation strongly attenuates aggregation of four-repeat tau protein, but ...[more]