Ontology highlight
ABSTRACT:
SUBMITTER: Chiu YC
PROVIDER: S-EPMC10517994 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Chiu Yu-Chuan YC Yeh Min-Chi MC Wang Chun-Hsiung CH Chen Yu-An YA Chang Hsiang H Lin Han-You HY Ho Meng-Chiao MC Lin Shih-Ming SM
Nature communications 20230923 1
Vibrio α-hemolysins (αHLs) are β-pore-forming toxins secreted by Vibrio pathogens, crucial for the facilitation of bacterial infections through host cell lysis. These toxins are produced as inactive precursors, requiring proteolytic maturation and membrane association for activation within host tissues. Here, we investigate Vibrio campbellii αHL (VcαHL), and establish that its hemolytic activity is significantly stimulated by calcium ions, with an EC<sub>50</sub> that aligns with physiological c ...[more]