Dataset Information

Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression.

ABSTRACT:

Background

The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined.

Methods

The NFL concentrations of 71 patients with TRD and 17 healthy controls were assessed. Patients with TRD were randomly administered a single infusion of 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms were assessed before infusion and sequentially at postinfusion timepoints (after 240 minutes and after 2-7 and 14 days) using the Hamilton Depression Rating Scale (HDRS).

Results

After adjustment for age, sex, and body mass index, patients with TRD were more likely to have higher concentrations of NFL than healthy controls (P < .001). A generalized estimating equation model with adjustments for infusion group, age, sex, body mass index, and baseline HDRS scores showed that baseline NFL concentrations were positively associated with subsequent HDRS scores following low-dose ketamine infusion (P = .038).

Discussion

Higher concentrations of NFL were observed among patients with TRD compared with healthy controls. Baseline NFL concentrations may predict the antidepressant effects of low-dose ketamine infusion.

SUBMITTER: Lin WC

PROVIDER: S-EPMC10519806 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Publications

Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression.

Lin Wei-Chen WC Su Tung-Ping TP Li Cheng-Ta CT Wu Hui-Ju HJ Bai Ya-Mei YM Liu Yu-Li YL Tu Pei-Chi PC Chen Mu-Hong MH

The international journal of neuropsychopharmacology 20230901 9

<h4>Background</h4>The role of neurofilament light chain (NFL) in treatment-resistant depression (TRD) is unclear. Whether baseline NFL concentrations are associated with the antidepressant effects of low-dose ketamine infusion has not been determined.<h4>Methods</h4>The NFL concentrations of 71 patients with TRD and 17 healthy controls were assessed. Patients with TRD were randomly administered a single infusion of 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms we ...[more]

PMID: 37490687

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Project description:Drug-resistant epilepsy is the most severe form of epilepsy and is frequently associated with cognitive decline. Whether drug-resistant epilepsy results in neurodegeneration or other types of brain injury is not known, and early detection of detrimental clinical trajectories would be clinically very useful. Blood biomarkers of brain injury reflect neurodegeneration or brain injury in several brain diseases but have not been extensively studied in epilepsy. We investigated a panel of such markers in a large epilepsy cohort with an emphasis on assessing differences between drug-resistant and monotherapy-controlled epilepsy. Blood neurofilament light, glial fibrillary acidic protein, total tau, S100 calcium-binding protein B and neuron-specific enolase concentrations were measured in 444 patients (aged ≥ 18 years) with epilepsy participating in a prospective regional Biobank study in Västra Götaland (Sweden). Multiple linear regression assessed associations between clinical variables and marker levels. Levels were then compared between patients with drug-resistant epilepsy (n = 101) and patients with monotherapy-controlled epilepsy (n = 164). We also performed logistic regression analysis to evaluate the significance of the markers as predictors of epilepsy status (drug-resistant epilepsy or monotherapy-controlled epilepsy) while controlling for clinical variables: age, sex, epilepsy duration, epilepsy type and lesions. All markers correlated with age. In younger patients (≤50 years), cases of drug-resistant epilepsy had higher levels of neurofilament light (P = 0.002) and glial fibrillary acidic protein (P = 0.006) compared with monotherapy-controlled epilepsy. After excluding patients with known structural lesions, neurofilament light levels remained significantly elevated in drug-resistant epilepsy versus monotherapy-controlled epilepsy (P = 0.029). Neurofilament light also emerged as a significant predictor of drug-resistant status in a logistic regression model following adjustments for clinical variables. Future studies should explore if neurofilament light can be used for surveillance of disease course and whether it reflects brain injury in drug-resistant epilepsy.

Dataset Information

Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression.

Background

Methods

Results

Discussion

Publications

Association of Neurofilament Light Chain With the Antidepressant Effects of Low-Dose Ketamine Infusion Among Patients With Treatment-Resistant Depression.

Similar Datasets

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