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Death begets failure in the heart.


ABSTRACT: Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications.

SUBMITTER: Foo RS 

PROVIDER: S-EPMC1052022 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature

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Death begets failure in the heart.

Foo Roger S-Y RS   Mani Kartik K   Kitsis Richard N RN  

The Journal of clinical investigation 20050301 3


Recently, low--but abnormal--rates of cardiomyocyte apoptosis have been observed in failing human hearts. Genetic and pharmacological studies suggest that this cell death is causally linked to heart failure in rodent models. Herein, we review these data and discuss potential therapeutic implications. ...[more]

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