Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC10520634 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Zhang Fang F Zhang Baokai B Ding Huihua H Li Xiangyue X Wang Xilin X Zhang Xiaomin X Liu Qiaojie Q Feng Qiuyun Q Han Mingshun M Chen Longlong L Qi Linlin L Yang Dan D Li Xiaojing X Zhu Xingguo X Zhao Qi Q Qiu Jiaqian J Zhu Zhengjiang Z Tang Huiru H Shen Nan N Wang Hongyan H Wei Bin B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230719 27
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with abnormal activation of the immune system. Recent attention is increasing about how aberrant lipid and cholesterol metabolism is linked together with type I interferon (IFN-I) signaling in the regulation of the pathogenesis of SLE. Here, a metabonomic analysis is performed and increased plasma concentrations of oxysterols, especially 7α, 25-dihydroxycholesterol (7α, 25-OHC), are identified in SLE patients. The authors find th ...[more]