Ontology highlight
ABSTRACT:
SUBMITTER: Yin S
PROVIDER: S-EPMC10520643 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Yin Songcheng S Liu Huifang H Zhou Zhijun Z Xu Xiaoyu X Wang Pengliang P Chen Wei W Deng Guofei G Wang Han H Yu Hong H Gu Liang L Huo Mingyu M Li Min M Zeng Leli L He Yulong Y Zhang Changhua C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230719 27
RNA-binding proteins (RBPs) play essential roles in tumorigenesis and progression, but their functions in gastric cancer (GC) remain largely elusive. Here, it is reported that Pumilio 1 (PUM1), an RBP, induces metabolic reprogramming through post-transcriptional regulation of DEP domain-containing mammalian target of rapamycin (mTOR)-interacting protein (DEPTOR) in GC. In clinical samples, elevated expression of PUM1 is associated with recurrence, metastasis, and poor survival. In vitro and in v ...[more]