Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC10522601 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Yang Yang Y Chu Chenyu C Liu Li L Wang Chenbing C Hu Chen C Rung Shengan S Man Yi Y Qu Yili Y
Nature communications 20230926 1
Skin scarring devoid of dermal appendages after severe trauma has unfavorable effects on aesthetic and physiological functions. Here we present a method for large-area wound regeneration using biodegradable aligned extracellular matrix scaffolds. We show that the implantation of these scaffolds accelerates wound coverage and enhances hair follicle neogenesis. We perform multimodal analysis, in combination with single-cell RNA sequencing and spatial transcriptomics, to explore the immune response ...[more]