Ontology highlight
ABSTRACT:
SUBMITTER: Evans JF
PROVIDER: S-EPMC10523142 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
European respiratory review : an official journal of the European Respiratory Society 20230927 169
Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway. mTORC1 activation enhances a plethora of anabolic cellular functions, mainly <i>via</i> the activation of mRNA translation through stimulation of ribosomal protein S6 kinase (S6K1)/ribosomal protein S6 (S6) and eukaryotic initiation factor 4E-binding protein 1 (4E-BP1)/eukaryotic translation ...[more]