Ontology highlight
ABSTRACT:
SUBMITTER: Lopes de Assis F
PROVIDER: S-EPMC10529190 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Lopes de Assis Felipe F Hoehn Kenneth B KB Zhang Xiaozhen X Kardava Lela L Smith Connor D CD El Merhebi Omar O Buckner Clarisa M CM Trihemasava Krittin K Wang Wei W Seamon Catherine A CA Chen Vicky V Schaughency Paul P Cheung Foo F Martins Andrew J AJ Chiang Chi-I CI Li Yuxing Y Tsang John S JS Chun Tae-Wook TW Kleinstein Steven H SH Moir Susan S
Cell reports 20230712 7
Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell analysis in three infection-naïve individuals. Integrated surface protein, transcriptomics, and B cell receptor (BCR) repertoire analysis of sorted plasmablasts and spike<sup>+</sup> (S-2P<sup>+</sup>) and S-2P<sup>-</sup> B cells reveal clonal expansion and ac ...[more]