Ontology highlight
ABSTRACT:
SUBMITTER: Petersen CE
PROVIDER: S-EPMC10529381 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Petersen Courtney E CE Sun Junhui J Silva Kavisha K Kosmach Anna A Balaban Robert S RS Murphy Elizabeth E
Cell reports 20230707 7
Mitochondrial Ca<sup>2+</sup> overload is proposed to regulate cell death via opening of the mitochondrial permeability transition pore. It is hypothesized that inhibition of the mitochondrial Ca<sup>2+</sup> uniporter (MCU) will prevent Ca<sup>2+</sup> accumulation during ischemia/reperfusion and thereby reduce cell death. To address this, we evaluate mitochondrial Ca<sup>2+</sup> in ex-vivo-perfused hearts from germline MCU-knockout (KO) and wild-type (WT) mice using transmural spectroscopy. M ...[more]