Ontology highlight
ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC105362 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Yu F F Thiesen J J Strätling W H WH
Nucleic acids research 20000501 10
Methyl-CpG-binding protein 2 (MeCP2) contains a transcriptional repression domain (TRD), which can act by recruitment of a large transcriptional co-repressor complex containing histone deacetylases HDAC1 and 2. We demonstrate here that transient transcription from the SV40 enhancer/promoter or the SV40 promoter is strongly repressed in a histone deacetylase-independent manner, since repression is not alleviated by Trichostatin A (TSA). In a mutational analysis, repression depends on a conserved ...[more]