PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming.
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ABSTRACT:
SUBMITTER: Liu B
PROVIDER: S-EPMC10541904 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Publications
PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming.
Liu Bing B Si Wen W Wei Bo B Zhang Xuan X Chen Peng P
Cell death discovery 20230929 1
PTP4A1 (Protein tyrosine phosphatase 4A1) is a protein tyrosine phosphatase that regulates a range of pro-oncogenic signaling pathways. Here, we report a novel role for PTP4A1 in oral squamous cell carcinoma (OSCC) growth and development. We show that PTP4A1 is frequently overexpressed in OSCC cells and tissues compared to adjacent non-tumor tissue. In OSCC, the overexpression of PTP4A1 increased cell growth and invasion in vitro, and enhanced tumor progression in vivo. At the molecular level, P ...[more]
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