Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC10545485 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Li Shanru S Liberti Derek D Zhou Su S Ying Yun Y Kong Jun J Basil Maria C MC Cardenas-Diaz Fabian L FL Shiraishi Kazushige K Morley Michael P MP Morrisey Edward E EE
Stem cell reports 20230817 9
AT2 cells harbor alveolar stem cell activity in the lung and can self-renew and differentiate into AT1 cells during homeostasis and after injury. To identify epigenetic pathways that control the AT2-AT1 regenerative response in the lung, we performed an organoid screen using a library of pharmacological epigenetic inhibitors. This screen identified DOT1L as a regulator of AT2 cell growth and differentiation. In vivo inactivation of Dot1l leads to precocious activation of both AT1 and AT2 gene ex ...[more]