Ontology highlight
ABSTRACT:
SUBMITTER: de Tribolet-Hardy J
PROVIDER: S-EPMC10547255 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
de Tribolet-Hardy Jonas J Thorball Christian W CW Forey Romain R Planet Evarist E Duc Julien J Coudray Alexandre A Khubieh Bara B Offner Sandra S Pulver Cyril C Fellay Jacques J Imbeault Michael M Turelli Priscilla P Trono Didier D
Genome research 20230801 8
Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by gene and segment duplication since the gene family first emerged more than 400 million years ago. Previous work has revealed that many KZFPs recognize transposable element (TE)-embedded sequences as genomic targets, and that KZFPs facilitate th ...[more]