Dataset Information

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

ABSTRACT:

Background

Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are unspecific and resemble those of benign pathologies, current diagnostic approaches are mostly initiated at advanced LC stages.

Methods

We developed a LC diagnosis test based on the analysis of distinct RNA isoforms expressed from the GATA6 and NKX2-1 gene loci, which are detected in exhaled breath condensates (EBCs). Levels of these transcript isoforms in EBCs were combined to calculate a diagnostic score (the LC score). In the present study, we aimed to confirm the applicability of the LC score for the diagnosis of early stage LC under clinical settings. Thus, we evaluated EBCs from patients with early stage, resectable non-small cell lung cancer (NSCLC), who were prospectively enrolled in the EMoLung study at three sites in Germany.

Results

LC score-based classification of EBCs confirmed its performance under clinical conditions, achieving a sensitivity of 95.7%, 91.3% and 84.6% for LC detection at stages I, II and III, respectively.

Conclusions

The LC score is an accurate and non-invasive option for early LC diagnosis and a valuable complement to LC screening procedures based on computed tomography.

SUBMITTER: Rubio K

PROVIDER: S-EPMC10547665 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

Rubio Karla K Müller Jason M JM Mehta Aditi A Watermann Iris I Olchers Till T Koch Ina I Wessels Sabine S Schneider Marc A MA Araujo-Ramos Tania T Singh Indrabahadur I Kugler Christian C Stoleriu Mircea Gabriel MG Kriegsmann Mark M Eichhorn Martin M Muley Thomas T Merkel Olivia M OM Braun Thomas T Ammerpohl Ole O Reck Martin M Tresch Achim A Barreto Guillermo G

Discover oncology 20231003 1

<h4>Background</h4>Lung cancer (LC) causes more deaths worldwide than any other cancer type. Despite advances in therapeutic strategies, the fatality rate of LC cases remains high (95%) since the majority of patients are diagnosed at late stages when patient prognosis is poor. Analysis of the International Association for the Study of Lung Cancer (IASLC) database indicates that early diagnosis is significantly associated with favorable outcome. However, since symptoms of LC at early stages are u ...[more]

PMID: 37787775

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Dataset Information

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

Background

Methods

Results

Conclusions

Publications

Preliminary results from the EMoLung clinical study showing early lung cancer detection by the LC score.

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