The role of DC-SIGN as a trans-receptor in infection by MERS-CoV.
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ABSTRACT:
SUBMITTER: Labiod N
PROVIDER: S-EPMC10552186 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
The role of DC-SIGN as a trans-receptor in infection by MERS-CoV.
Labiod Nuria N Luczkowiak Joanna J Tapia María M MM Lasala Fátima F Delgado Rafael R
Frontiers in cellular and infection microbiology 20230921
DC-SIGN is a C-type lectin expressed in myeloid cells such as immature dendritic cells and macrophages. Through glycan recognition in viral envelope glycoproteins, DC-SIGN has been shown to act as a receptor for a number of viral agents such as HIV, Ebola virus, SARS-CoV, and SARS-CoV-2. Using a system of Vesicular Stomatitis Virus pseudotyped with MERS-CoV spike protein, here, we show that DC-SIGN is partially responsible for MERS-CoV infection of dendritic cells and that DC-SIGN efficiently me ...[more]
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