Dataset Information

Proton Beam Therapy versus Radiofrequency Ablation for Patients with Treatment-Naive Single Hepatocellular Carcinoma: A Propensity Score Analysis.

ABSTRACT:

Introduction

Proton beam therapy (PBT) is known to be an effective locoregional treatment for hepatocellular carcinoma (HCC). However, few comparative studies in treatment-naïve cases have been reported. The aim of this study was to compare the survival outcomes of PBT with those of radiofrequency ablation (RFA) in patients with treatment-naïve solitary HCC.

Methods

Ninety-five consecutive patients with treatment-naïve HCC, a single nodule measuring ≤5 cm in diameter, and a Child-Pugh score of ≤8 who were treated with PBT at the University of Tsukuba Hospital between 2001 and 2013 were enrolled in the study. In addition, 836 patients with treatment-naïve HCC treated by RFA at the University of Tokyo Hospital during the same period were analyzed as controls. Recurrence-free survival (RFS) and overall survival (OS) were compared in 83 patient pairs after propensity score matching.

Results

The 1-year, 3-year, and 5-year RFS rates were 86.6%, 49.5%, and 35.5%, respectively, in the PBT group and 59.5%, 34.0%, and 20.9% in the RFA group (p = 0.058); the respective OS rates were 97.6%, 77.8%, and 57.1% in the PBT group and 95.1%, 81.7%, and 67.7% in the RFA group (p = 0.16). Regarding adverse effects, no grade 3 or higher adverse events were noted in the PBT; however, two grade 3 adverse events occurred within 30 days of RFA in the RFA group: one hemoperitoneum and one hemothorax.

Discussion

After propensity score matching, PBT showed no significant difference in RFS and OS compared to RFA. PBT can be an alternative for patients with solitary treatment-naïve HCC.

SUBMITTER: Sekino Y

PROVIDER: S-EPMC10561322 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Proton Beam Therapy versus Radiofrequency Ablation for Patients with Treatment-Naïve Single Hepatocellular Carcinoma: A Propensity Score Analysis.

Sekino Yuta Y Tateishi Ryosuke R Fukumitsu Nobuyoshi N Okumura Toshiyuki T Maruo Kazushi K Iizumi Takashi T Numajiri Haruko H Mizumoto Masashi M Minami Tatsuya T Nakagomi Ryo R Sato Masaya M Asaoka Yoshinari Y Nakagawa Hayato H Hayata Yuki Y Fujiwara Naoto N Shiina Shuichiro S Koike Kazuhiko K Sakurai Hideyuki H

Liver cancer 20221206 4

<h4>Introduction</h4>Proton beam therapy (PBT) is known to be an effective locoregional treatment for hepatocellular carcinoma (HCC). However, few comparative studies in treatment-naïve cases have been reported. The aim of this study was to compare the survival outcomes of PBT with those of radiofrequency ablation (RFA) in patients with treatment-naïve solitary HCC.<h4>Methods</h4>Ninety-five consecutive patients with treatment-naïve HCC, a single nodule measuring ≤5 cm in diameter, and a Child- ...[more]

PMID: 37817755

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