Ontology highlight
ABSTRACT:
SUBMITTER: Casadevall A
PROVIDER: S-EPMC105619 | biostudies-literature | 1998 Jun
REPOSITORIES: biostudies-literature
Casadevall A A Cleare W W Feldmesser M M Glatman-Freedman A A Goldman D L DL Kozel T R TR Lendvai N N Mukherjee J J Pirofski L A LA Rivera J J Rosas A L AL Scharff M D MD Valadon P P Westin K K Zhong Z Z
Antimicrobial agents and chemotherapy 19980601 6
The murine monoclonal antibody (MAb) 18B7 [immunoglobulin G1(kappa)] is in preclinical development for treatment of Cryptococcus neoformans infections. In anticipation of its use in humans, we defined the serological and biological properties of MAb 18B7 in detail. Structural comparison to the related protective MAb 2H1 revealed conservation of the antigen binding site despite several amino acid differences. MAb 18B7 was shown by immunofluorescence and agglutination studies to bind to all four s ...[more]