Preclinical 3D-model supports an invisibility cloak for adenoid cystic carcinoma.
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ABSTRACT:
SUBMITTER: Chakraborty R
PROVIDER: S-EPMC10562364 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Preclinical 3D-model supports an invisibility cloak for adenoid cystic carcinoma.
Chakraborty Rajdeep R Darido Charbel C Chien Arthur A Tay Aidan A Vickery Karen K Hu Honghua H Liu Fei F Ranganathan Shoba S
Scientific reports 20231009 1
The tumour-cell based initiation of immune evasion project evaluated the role of Gipie in adenoid cystic carcinoma (ACC) and mucoepidermoid carcinoma (A-253), from ninety-six 3D-ACC and A-253-immune co-culture models using natural killer cells (NK), and Jurkat cells (JK). Abnormal ACC morphology was observed in 3D-ACC immune co-culture models. Gipie-silencing conferred a "lymphoblast-like" morphology to ACC cells, a six-fold increase in apoptotic cells (compared to unaltered ACC cells, P ≤ 0.000 ...[more]
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