Dataset Information

European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI.

ABSTRACT:

Purpose

Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to the intensive care unit (ICU). We aim to report the clinical characteristics of ICU-admitted patients due to nosocomial LRTI and to describe their microbiology and clinical outcomes.

Methods

A prospective observational study was conducted in 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics and outcomes of ventilator-associated pneumonia (VAP), ventilator-associated tracheobronchitis (VAT), ICU hospital-acquired pneumonia (ICU-HAP), HAP that required invasive ventilation (VHAP), and HAP in patients transferred to the ICU without invasive mechanical ventilation were collected. The clinical diagnosis and treatments were per clinical practice and not per protocol. Descriptive statistics were used to compare the study groups.

Results

1060 patients with LRTI (72.5% male sex, median age 64 [50-74] years) were included in the study; 160 (15.1%) developed VAT, 556 (52.5%) VAP, 98 (9.2%) ICU-HAP, 152 (14.3%) HAP, and 94 (8.9%) VHAP. Patients with VHAP had higher serum procalcitonin (PCT) and Sequential Organ Failure Assessment (SOFA) scores. Patients with VAP or VHAP developed acute kidney injury, acute respiratory distress syndrome, multiple organ failure, or septic shock more often. One thousand eight patients had microbiological samples, and 711 (70.5%) had etiological microbiology identified. The most common microorganisms were Pseudomonas aeruginosa (18.4%) and Klebsiella spp (14.4%). In 382 patients (36%), the causative pathogen shows some antimicrobial resistance pattern. ICU, hospital and 28-day mortality were 30.8%, 37.5% and 27.5%, respectively. Patients with VHAP had the highest ICU, in-hospital and 28-day mortality rates.

Conclusion

VHAP patients presented the highest mortality among those admitted to the ICU. Multidrug-resistant pathogens frequently cause nosocomial LRTI in this multinational cohort study.

SUBMITTER: Martin-Loeches I

PROVIDER: S-EPMC10562498 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI.

Martin-Loeches Ignacio I Reyes Luis Felipe LF Nseir Saad S Ranzani Otavio O Povoa Pedro P Diaz Emili E Schultz Marcus J MJ Rodríguez Alejandro H AH Serrano-Mayorga Cristian C CC De Pascale Gennaro G Navalesi Paolo P Panigada Mauro M Coelho Luis Miguel LM Skoczynski Szymon S Esperatti Mariano M Cortegiani Andrea A Aliberti Stefano S Caricato Anselmo A Salzer Helmut J F HJF Ceccato Adrian A Civljak Rok R Soave Paolo Maurizio PM Luyt Charles-Edouard CE Ekren Pervin Korkmaz PK Rios Fernando F Masclans Joan Ramon JR Marin Judith J Iglesias-Moles Silvia S Nava Stefano S Chiumello Davide D Bos Lieuwe D LD Artigas Antoni A Froes Filipe F Grimaldi David D Taccone Fabio Silvio FS Antonelli Massimo M Torres Antoni A

Intensive care medicine 20231009 10

<h4>Purpose</h4>Lower respiratory tract infections (LRTI) are the most frequent infectious complication in patients admitted to the intensive care unit (ICU). We aim to report the clinical characteristics of ICU-admitted patients due to nosocomial LRTI and to describe their microbiology and clinical outcomes.<h4>Methods</h4>A prospective observational study was conducted in 13 countries over two continents from 9th May 2016 until 16th August 2019. Characteristics and outcomes of ventilator-assoc ...[more]

PMID: 37812242

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Dataset Information

European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI.

Purpose

Methods

Results

Conclusion

Publications

European Network for ICU-Related Respiratory Infections (ENIRRIs): a multinational, prospective, cohort study of nosocomial LRTI.

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