Ontology highlight
ABSTRACT:
SUBMITTER: Hesse S
PROVIDER: S-EPMC10562643 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20231004
Rhodanines and their derivatives are known to have many pharmacological activities that can be modulated through different functionalization sites. One of the most studied modification in those scaffolds is the introduction of a benzylidene moiety on C5 via a Knoevenagel reaction. Here, a facile synthesis of 5-arylidenerhodanines via a Knoevenagel reaction in an ʟ-proline-based deep eutectic solvent (DES) is reported. This method is fast (1 h at 60 °C), easy, catalyst-free and sustainable as no ...[more]