Ontology highlight
ABSTRACT:
SUBMITTER: Wu M
PROVIDER: S-EPMC10565630 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Wu Ming M Luo Zijin Z Cai Zhixiong Z Mao Qianqian Q Li Zhenli Z Li Hao H Zhang Cao C Zhang Yuting Y Zhong Aoxue A Wu Liming L Liu Xiaolong X
EMBO molecular medicine 20230808 10
Neoantigens are emerging as attractive targets to develop personalized cancer vaccines, but their immunization efficacy is severely hampered by their restricted accessibility to lymphoid tissues where immune responses are initiated. Leveraging the capability of red blood cells (RBCs) to capture and present pathogens in peripheral blood to the antigen-presenting cells (APCs) in spleen, we developed a RBC-driven spleen targeting strategy to deliver DNA vaccine encoding hepatocellular carcinoma (HC ...[more]