Microbial-host-isozyme: unveiling a new era in microbiome-host interaction.
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ABSTRACT:
SUBMITTER: Miao L
PROVIDER: S-EPMC10566401 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
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Microbial-host-isozyme: unveiling a new era in microbiome-host interaction.
Miao Lei L Tilg Herbert H Zheng Ming-Hua MH
Gut microbes 20231010 2
Wang K. et al. introduced the concept of Microbial-Host isozymes (MHIs) and highlighted their role in mediating microbiota-host interactions. They identified bacterial-derived DPP4 as an isoenzyme affecting glucose tolerance and showed that host DPP4 inhibitors may not effectively target bacterial DPP4. They developed an MHI screen system, identifying 71 MHIs in healthy gut microbiota. Among them, DPP4 isozymes degrade GLP-1, explaining variable responses to sitagliptin. This breakthrough opens ...[more]
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