Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information.
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ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC10568094 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Profiling the inflammatory bowel diseases using genetics, serum biomarkers, and smoking information.
Liu Ruize R Li Dalin D Haritunians Talin T Ruan Yunfeng Y Daly Mark J MJ Huang Hailiang H McGovern Dermot P B DPB
iScience 20230926 10
Crohn's disease (CD) and ulcerative colitis (UC) are two etiologically related yet distinctive subtypes of the inflammatory bowel diseases (IBD). Differentiating CD from UC can be challenging using conventional clinical approaches in a subset of patients. We designed and evaluated a novel molecular-based prediction model aggregating genetics, serum biomarkers, and tobacco smoking information to assist the diagnosis of CD and UC in over 30,000 samples. A joint model combining genetics, serum biom ...[more]
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