Dataset Information

Flushing Home Plumbing Pipes Contaminated with Aqueous Film-Forming Foam Containing Per- and Polyfluoroalkyl Substances.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) from aqueous film forming foam (AFFF) can be accidentally backflushed into drinking water systems during firefighting operations or at industrial facilities. If this contaminated water enters household plumbing systems, homeowners may need to decontaminate their plumbing. This study examines the persistence of PFAS from AFFF on home plumbing, along with the effects of flushing and stagnation. Two sources of AFFF were investigated, representing older formulations (that contain longer chain PFAS) and newer formulations (that contain shorter chain PFAS). Experiments were conducted in copper, polyvinyl chloride (PVC), and cross-linked polyethylene (PEX) pipes with flushing after contamination followed by intermittent flow and periods of stagnation meant to mimic typical household use. Flushing immediately reduced the PFAS concentration in water leaving the pipe by 99.95% to 99.99%. However, PFAS concentration increased after periods of stagnation, corresponding to slow release of adhered PFAS. Flushing may be a valuable part of the decontamination process, but flushing parameters and duration need to be optimized for local conditions.

SUBMITTER: Szabo J

PROVIDER: S-EPMC10569108 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Flushing Home Plumbing Pipes Contaminated with Aqueous Film-Forming Foam Containing Per- and Polyfluoroalkyl Substances.

Szabo Jeffrey J Witt Sue S Sojda Nicole N Schupp Don D Magnuson Matthew M

Journal of environmental engineering (New York, N.Y.) 20230901 9

Per- and polyfluoroalkyl substances (PFAS) from aqueous film forming foam (AFFF) can be accidentally backflushed into drinking water systems during firefighting operations or at industrial facilities. If this contaminated water enters household plumbing systems, homeowners may need to decontaminate their plumbing. This study examines the persistence of PFAS from AFFF on home plumbing, along with the effects of flushing and stagnation. Two sources of AFFF were investigated, representing older for ...[more]

PMID: 37829295

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Project description:Drinking water contaminated by fluorosurfactant-based aqueous film-forming foams (AFFF) is a source of human exposure to poly- and perfluoroalkyl substances (PFAS). However, assessment of bioaccumulation potentials of diverse PFAS in commercial products such as AFFF have been insufficient and challenging, especially due to a lack of analytical standards. Here we explore the value of suspect screening, equilibrium dialysis, and molecular-docking simulations to identify potentially bioaccumulative PFAS. We exposed human serum albumin (HSA) protein to dilutions of a legacy AFFF produced by 3M in 1999 using equilibrium dialysis and screened in-vitro protein-binding affinities using high-resolution mass spectrometry (HRMS). Through suspect screening, we identified 32 PFAS and 18 hydrocarbon surfactants in the AFFF that bound to HSA. Quantification of noncovalent association constants for 26 PFAS standards confirmed that many PFAS, including the short-chain perfluoropropane sulfonic acid (log Ka= 4.1 ± 0.2 M-1), exhibit strong binding affinities with HSA. At least five PFAS in AFFF (including three PFAS with less than five perfluorocarbons) remained bound to the precipitated HSA pellet after extensive solvent washing-an indication of high PFAS binding potential. Three PFAS (PFBS, PFOS, and PFOA) were confirmed in the protein pellet with analytical standards and quantified after acid digestion-this sample fraction accounted for 5 to 20% of each compound mass in the sample. We calculated pseudo-bioconcentration factors (BCFpseudo) for PFAS that suspect screening flagged as noncovalently bound or potentially covalently bound. Most PFAS exhibiting high BCFpseudo, especially those with seven perfluorocarbons, contained a carboxylic acid or a sulfonic acid. Finally, we used molecular docking to simulate HSA binding affinities for 62 ligands (26 PFAS targets, 18 PFAS qualified in AFFF, and 18 hydrocarbon surfactants qualified in AFFF). We found that molecular docking can effectively separate HSA-binding and -nonbinding compounds in AFFF. In-vitro and in-silico approaches described in this study provide replicable, high-throughput workflows for assessing bioaccumulation potentials of diverse PFAS in commercial products.

Project description:BackgroundPer- and polyfluoroalkyl substances (PFAS) are a chemical class widely used in industrial and commercial applications because of their unique physical and chemical properties. Between 2013 and 2016 PFAS were detected in public water systems and private wells in El Paso County, Colorado. The contamination was likely due to aqueous film forming foams used at a nearby Air Force base.ObjectiveTo cross-sectionally describe the serum concentrations of PFAS in a highly exposed community, estimate associations with drinking water source, and explore potential demographic and behavioral predictors.MethodsIn June 2018, serum PFAS concentrations were quantified and questionnaires administered in 213 non-smoking adult (ages 19-93) participants residing in three affected water districts. Twenty PFAS were quantified and those detected in >50% of participants were analyzed: perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorononanoate (PFNA) and perfluoroheptane sulfonate (PFHpS). Unadjusted associations were estimated between serum PFAS concentrations and several predictors, including water consumption, demographics, personal behaviors and employment. A multiple linear regression model estimated adjusted associations with smoking history.ResultsStudy participants' median PFHxS serum concentration (14.8 ng/mL) was approximately 12 times as high as the U.S. national average. Median serum concentrations for PFOS, PFOA, PFNA and PFHpS were 9.7 ng/mL, 3.0 ng/mL, 0.4 ng/mL and 0.2 ng/mL, respectively. Determinants of PFHxS serum concentrations were water district of residence, frequency of bottled water consumption, age, race/ethnicity, and smoking history. Determinants of serum concentrations for the other four PFAS evaluated included: water district of residence, bottled water consumption, age, sex, race/ethnicity, smoking history, and firefighter or military employment.ConclusionsDeterminants of serum concentrations for multiple PFAS, including PFHxS, included water district of residence and frequency of bottled water consumption. Participants' dominant PFAS exposure route was likely consumption of PFAS-contaminated water, but certain demographic and behavioral characteristics also predicted serum concentrations.

Dataset Information

Flushing Home Plumbing Pipes Contaminated with Aqueous Film-Forming Foam Containing Per- and Polyfluoroalkyl Substances.

Publications

Flushing Home Plumbing Pipes Contaminated with Aqueous Film-Forming Foam Containing Per- and Polyfluoroalkyl Substances.

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