Ontology highlight
ABSTRACT:
SUBMITTER: Cholak S
PROVIDER: S-EPMC10569317 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Cholak Spencer S Saville James W JW Zhu Xing X Berezuk Alison M AM Tuttle Katharine S KS Haji-Ghassemi Omid O Alvarado Francisco J FJ Van Petegem Filip F Subramaniam Sriram S
Structure (London, England : 1993) 20230515 7
The coordinated release of Ca<sup>2+</sup> from the sarcoplasmic reticulum (SR) is critical for excitation-contraction coupling. This release is facilitated by ryanodine receptors (RyRs) that are embedded in the SR membrane. In skeletal muscle, activity of RyR1 is regulated by metabolites such as ATP, which upon binding increase channel open probability (P<sub>o</sub>). To obtain structural insights into the mechanism of RyR1 priming by ATP, we determined several cryo-EM structures of RyR1 bound ...[more]