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Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.

ABSTRACT: The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance.

SUBMITTER: Troyer JM

PROVIDER: S-EPMC105694 | biostudies-literature | 1998 Jul

REPOSITORIES: biostudies-literature

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Detection of point mutations in rpoB gene of rifampin-resistant Rickettsia typhi.

Troyer J M JM Radulovic S S Andersson S G SG Azad A F AF

Antimicrobial agents and chemotherapy 19980701 7

The rpoB gene of rifampin-resistant Rickettsia typhi (Rif mutant) and wild-type R. typhi were sequenced and compared. The Rif mutant rpoB had three nucleotide substitutions, which resulted in amino acid changes at residues 151, 201, and 271 and may be the basis for the rifampin resistance. ...[more]

PMID: 9661032

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<i>rpoB</i> gene mutations in rifampin-resistant <i>Mycobacterium tuberculosis</i> isolates from rural areas of Zhejiang, China.

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