A cellular resolution atlas of Broca's area.
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ABSTRACT:
SUBMITTER: Costantini I
PROVIDER: S-EPMC10569704 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
A cellular resolution atlas of Broca's area.
Costantini Irene I Morgan Leah L Yang Jiarui J Balbastre Yael Y Varadarajan Divya D Pesce Luca L Scardigli Marina M Mazzamuto Giacomo G Gavryusev Vladislav V Castelli Filippo Maria FM Roffilli Matteo M Silvestri Ludovico L Laffey Jessie J Raia Sophia S Varghese Merina M Wicinski Bridget B Chang Shuaibin S Chen Ichun Anderson IA Wang Hui H Cordero Devani D Vera Matthew M Nolan Jackson J Nestor Kimberly K Mora Jocelyn J Iglesias Juan Eugenio JE Garcia Pallares Erendira E Evancic Kathryn K Augustinack Jean C JC Fogarty Morgan M Dalca Adrian V AV Frosch Matthew P MP Magnain Caroline C Frost Robert R van der Kouwe Andre A Chen Shih-Chi SC Boas David A DA Pavone Francesco Saverio FS Fischl Bruce B Hof Patrick R PR
Science advances 20231012 41
Brain cells are arranged in laminar, nuclear, or columnar structures, spanning a range of scales. Here, we construct a reliable cell census in the frontal lobe of human cerebral cortex at micrometer resolution in a magnetic resonance imaging (MRI)-referenced system using innovative imaging and analysis methodologies. MRI establishes a macroscopic reference coordinate system of laminar and cytoarchitectural boundaries. Cell counting is obtained with a digital stereological approach on the 3D reco ...[more]
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Project description:ObjectiveBroca's aphasia is a syndrome of impaired fluency with retained comprehension. The authors used an unbiased algorithm to examine which neuroanatomical areas are most likely to result in Broca's aphasia following surgical lesions.MethodsPatients were prospectively evaluated with standardized language batteries before and after surgery. Broca's area was defined anatomically as the pars opercularis and triangularis of the inferior frontal gyrus. Broca's aphasia was defined by the Western Aphasia Battery language assessment. Resections were outlined from MRI scans to construct 3D volumes of interest. These were aligned using a nonlinear transformation to Montreal Neurological Institute brain space. A voxel-based lesion-symptom mapping (VLSM) algorithm was used to test for areas statistically associated with Broca's aphasia when incorporated into a resection, as well as areas associated with deficits in fluency independent of Western Aphasia Battery classification. Postoperative MRI scans were reviewed in blinded fashion to estimate the percentage resection of Broca's area compared to areas identified using the VLSM algorithm.ResultsA total of 289 patients had early language evaluations, of whom 19 had postoperative Broca's aphasia. VLSM analysis revealed an area that was highly correlated (p < 0.001) with Broca's aphasia, spanning ventral sensorimotor cortex and supramarginal gyri, as well as extending into subcortical white matter tracts. Reduced fluency scores were significantly associated with an overlapping region of interest. The fluency score was negatively correlated with fraction of resected precentral, postcentral, and supramarginal components of the VLSM area.ConclusionsBroca's aphasia does not typically arise from neurosurgical resections in Broca's area. When Broca's aphasia does occur after surgery, it is typically in the early postoperative period, improves by 1 month, and is associated with resections of ventral sensorimotor cortex and supramarginal gyri.
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