A fast non-parametric test of association for multiple traits.
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ABSTRACT:
SUBMITTER: Garrido-Martin D
PROVIDER: S-EPMC10571397 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
A fast non-parametric test of association for multiple traits.
Garrido-Martín Diego D Calvo Miquel M Reverter Ferran F Guigó Roderic R
Genome biology 20231012 1
The increasing availability of multidimensional phenotypic data in large cohorts of genotyped individuals requires efficient methods to identify genetic effects on multiple traits. Permutational multivariate analysis of variance (PERMANOVA) offers a powerful non-parametric approach. However, it relies on permutations to assess significance, which hinders the analysis of large datasets. Here, we derive the limiting null distribution of the PERMANOVA test statistic, providing a framework for the f ...[more]
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