Ontology highlight
ABSTRACT:
SUBMITTER: Lee E
PROVIDER: S-EPMC10575726 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Lee Eunhyeong E O'Keefe Sophie S Leong Alessandra A Park Ha-Ram HR Varadarajan Janani J Chowdhury Subrata S Hiner Shannon S Kim Sungsoo S Shiva Anahita A Friedman Richard A RA Remotti Helen H Fojo Tito T Yang Hee Won HW Thurston Gavin G Kim Minah M
The Journal of clinical investigation 20231016 20
Improving the management of metastasis in pancreatic neuroendocrine tumors (PanNETs) is critical, as nearly half of patients with PanNETs present with liver metastases, and this accounts for the majority of patient mortality. We identified angiopoietin-2 (ANGPT2) as one of the most upregulated angiogenic factors in RNA-Seq data from human PanNET liver metastases and found that higher ANGPT2 expression correlated with poor survival rates. Immunohistochemical staining revealed that ANGPT2 was loca ...[more]