Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques.

ABSTRACT: Latent viral reservoir is recognized as the major obstacle to achieving a functional cure for HIV infection. We previously reported that arsenic trioxide (As₂O₃) combined with antiretroviral therapy (ART) can reactivate the viral reservoir and delay viral rebound after ART interruption in chronically simian immunodeficiency virus (SIV)-infected macaques. In this study, we further investigated the effect of As₂O₃ independent of ART in chronically SIV-infected macaques. We found that As₂O₃-only treatment significantly increased the CD4/CD8 ratio, improved SIV-specific T cell responses, and reactivated viral latency in chronically SIVmac239-infected macaques. RNA-sequencing analysis revealed that As₂O₃ tre

SUBMITTER: He Y 

PROVIDER: S-EPMC10581169 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature