Ontology highlight
ABSTRACT:
SUBMITTER: Heimli M
PROVIDER: S-EPMC10584817 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Heimli Marte M Tennebø Flåm Siri S Sagsveen Hjorthaug Hanne H Bjørnstad Pål Marius PM Chernigovskaya Maria M Le Quy Khang QK Tekpli Xavier X Greiff Victor V Lie Benedicte Alexandra BA
Scientific reports 20231018 1
Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negative selection, or to agonist selection and differentiation into unconventional lineages such as regulatory T cells and CD8[Formula: see text] T cells. To explore the effect of the adaptive immune receptor repertoire on thymocyte developmental decisions, we performed single cell adaptive imm ...[more]