Identification of a RAD51B enhancer variant for susceptibility and progression to glioma.

ABSTRACT:

Background

RAD51B plays a significant role in homologous recombination-mediated repair of DNA double-strand breaks. Many enhancer variants are involved in cancer development and progression. However, the significance of enhancer variants of RAD51B in glioma susceptibility and progression remains unclear.

Methods

A case-control study consisting of 1056 individuals was conducted to evaluate the associations of enhancer variants of RAD51B with glioma susceptibility and progression. Sequenom MassARRAY technology was used for genotyping. The function of enhancer variants was explored by biochemical assays.

Results

A significantly decreased risk of glioma was associated with rs6573816 GC genotype compared with rs6573816 GG genotype (OR = 0.66, 95% CI 0.45-0.97; P = 0.034).

SUBMITTER: Huang L 

PROVIDER: S-EPMC10585866 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature