Reprogramming megakaryocytes to engineer platelets as delivery vehicles.
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ABSTRACT:
SUBMITTER: Javdan SB
PROVIDER: S-EPMC10592833 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
Programming megakaryocytes to produce engineered platelets for delivering non-native proteins.
Islam Farhana F Javdan Shwan B SB Lewis Mitchell R MR Craig James D JD Wu Han H Deans Tara L TL
bioRxiv : the preprint server for biology 20250127
Platelets are anucleate cells naturally filled with secretory granules that store large amounts of protein to be released in response to certain physiological conditions. Cell engineering can endow platelets with the ability to deliver non-native proteins by modifying them as they develop during the cell fate process. This study presents a strategy to efficiently generate mouse platelets from pluripotent stem cells and demonstrates their potential as bioengineered protein delivery platforms. By ...[more]
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