Ontology highlight
ABSTRACT:
SUBMITTER: Tachedjian G
PROVIDER: S-EPMC105992 | biostudies-literature | 1998 Nov
REPOSITORIES: biostudies-literature
Tachedjian G G French M M Mills J J
Antimicrobial agents and chemotherapy 19981101 11
Human immunodeficiency virus type 1 (HIV-1) isolates obtained from a patient with AIDS were assessed for coresistance to foscarnet and zidovudine. An HIV-1 strain (AP20) coresistant to foscarnet and zidovudine was isolated after 20 months of continuous combination therapy. The reverse transcriptase (RT) gene of AP20 had 41 substitutions which were different from the HXB2-D sequence and 9 that were different from the sequence of its foscarnet-sensitive, zidovudine-resistant progenitor virus (AP6) ...[more]