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Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone.


ABSTRACT: A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths. Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir followed by sustained human-to-human infections. It has been reported that the EBOV genome variation might have an effect on the efficacy of sequence-based virus detection and candidate therapeutics. However, only limited viral information has been available since July 2014, when the outbreak entered a rapid growth phase. Here we describe 175 full-length EBOV genome sequences from five severely stricken districts in Sierra Leone from 28 September to 11 November 2014. We found that the 2014 EBOV has become more phylogenetically and genetically diverse from July to November 2014, characterized by the emergence of multiple novel lineages. The substitution rate for the 2014 EBOV was estimated to be 1.23 × 10(-3) substitutions per site per year (95% highest posterior density interval, 1.04 × 10(-3) to 1.41 × 10(-3) substitutions per site per year), approximating to that observed between previous EBOV outbreaks. The sharp increase in genetic diversity of the 2014 EBOV warrants extensive EBOV surveillance in Sierra Leone, Guinea and Liberia to better understand the viral evolution and transmission dynamics of the ongoing outbreak. These data will facilitate the international efforts to develop vaccines and therapeutics.

SUBMITTER: Tong YG 

PROVIDER: S-EPMC10601608 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature

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Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone.

Tong Yi-Gang YG   Shi Wei-Feng WF   Liu Di D   Qian Jun J   Liang Long L   Bo Xiao-Chen XC   Liu Jun J   Ren Hong-Guang HG   Fan Hang H   Ni Ming M   Sun Yang Y   Jin Yuan Y   Teng Yue Y   Li Zhen Z   Kargbo David D   Dafae Foday F   Kanu Alex A   Chen Cheng-Chao CC   Lan Zhi-Heng ZH   Jiang Hui H   Luo Yang Y   Lu Hui-Jun HJ   Zhang Xiao-Guang XG   Yang Fan F   Hu Yi Y   Cao Yu-Xi YX   Deng Yong-Qiang YQ   Su Hao-Xiang HX   Sun Yu Y   Liu Wen-Sen WS   Wang Zhuang Z   Wang Cheng-Yu CY   Bu Zhao-Yang ZY   Guo Zhen-Dong ZD   Zhang Liu-Bo LB   Nie Wei-Min WM   Bai Chang-Qing CQ   Sun Chun-Hua CH   An Xiao-Ping XP   Xu Pei-Song PS   Zhang Xiang-Li-Lan XL   Huang Yong Y   Mi Zhi-Qiang ZQ   Yu Dong D   Yao Hong-Wu HW   Feng Yong Y   Xia Zhi-Ping ZP   Zheng Xue-Xing XX   Yang Song-Tao ST   Lu Bing B   Jiang Jia-Fu JF   Kargbo Brima B   He Fu-Chu FC   Gao George F GF   Cao Wu-Chun WC  

Nature 20150513 7563


A novel Ebola virus (EBOV) first identified in March 2014 has infected more than 25,000 people in West Africa, resulting in more than 10,000 deaths. Preliminary analyses of genome sequences of 81 EBOV collected from March to June 2014 from Guinea and Sierra Leone suggest that the 2014 EBOV originated from an independent transmission event from its natural reservoir followed by sustained human-to-human infections. It has been reported that the EBOV genome variation might have an effect on the eff  ...[more]

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