Ontology highlight
ABSTRACT:
SUBMITTER: Sudbeck EA
PROVIDER: S-EPMC106026 | biostudies-literature | 1998 Dec
REPOSITORIES: biostudies-literature
Sudbeck E A EA Mao C C Vig R R Venkatachalam T K TK Tuel-Ahlgren L L Uckun F M FM
Antimicrobial agents and chemotherapy 19981201 12
Two highly potent dihydroalkoxybenzyloxopyrimidine (DABO) derivatives targeting the nonnucleoside inhibitor (NNI) binding site of human immunodeficiency virus (HIV) reverse transcriptase (RT) have been designed based on the structure of the NNI binding pocket and tested for anti-HIV activity. Our lead DABO derivative, 5-isopropyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-on e, elicited potent inhibitory activity against purified recombinant HIV RT and abrogated HIV replication in pe ...[more]