An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors.
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ABSTRACT:
SUBMITTER: O'Connor JJ
PROVIDER: S-EPMC10610136 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Publications
An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors.
O'Connor Joseph J JJ Ferraris Dana D Fehr Anthony R AR
Pathogens (Basel, Switzerland) 20231007 10
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose binding protein and ADP-ribosylhydrolase that promotes replication and blocks IFN responses, though the precise mechanisms it uses to carry out these functions remain unknown. Over the past 3 years following the onset of COVID-19, several groups have us ...[more]
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