Ontology highlight
ABSTRACT:
SUBMITTER: Nasu Y
PROVIDER: S-EPMC10611801 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Nasu Yusuke Y Aggarwal Abhi A Le Giang N T GNT Vo Camilla Trang CT Kambe Yuki Y Wang Xinxing X Beinlich Felix R M FRM Lee Ashley Bomin AB Ram Tina R TR Wang Fangying F Gorzo Kelsea A KA Kamijo Yuki Y Boisvert Marc M Nishinami Suguru S Kawamura Genki G Ozawa Takeaki T Toda Hirofumi H Gordon Grant R GR Ge Shaoyu S Hirase Hajime H Nedergaard Maiken M Paquet Marie-Eve ME Drobizhev Mikhail M Podgorski Kaspar K Campbell Robert E RE
Nature communications 20231027 1
L-Lactate is increasingly appreciated as a key metabolite and signaling molecule in mammals. However, investigations of the inter- and intra-cellular dynamics of L-lactate are currently hampered by the limited selection and performance of L-lactate-specific genetically encoded biosensors. Here we now report a spectrally and functionally orthogonal pair of high-performance genetically encoded biosensors: a green fluorescent extracellular L-lactate biosensor, designated eLACCO2.1, and a red fluore ...[more]