Ontology highlight
ABSTRACT:
SUBMITTER: Martinez-Martinez YB
PROVIDER: S-EPMC10613213 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Martinez-Martinez Yazmin B YB Huante Matthew B MB Chauhan Sadhana S Naqvi Kubra F KF Bharaj Preeti P Endsley Janice J JJ
NPJ vaccines 20231028 1
Therapeutic vaccines have promise as adjunctive treatment for tuberculosis (TB) or as preventives against TB relapse. An important development challenge is the limited understanding of T helper (Th) cell roles during these stages of disease. A murine model of TB relapse was used to identify changes in Th populations and cytokine microenvironment. Active TB promoted expansion of Th1, Th2, Th17, and Th22 cells and cytokines in the lung. Following drug therapy, pulmonary Th17 and Th22 cells contrac ...[more]