Ontology highlight
ABSTRACT:
SUBMITTER: Iyoda T
PROVIDER: S-EPMC10616117 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Iyoda Tomonori T Shimizu Kanako K Endo Takaho T Watanabe Takashi T Taniuchi Ichiro I Aoshima Honoka H Satoh Mikiko M Nakazato Hiroshi H Yamasaki Satoru S Fujii Shin-Ichiro SI
Communications biology 20231030 1
After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1<sup>+</sup> long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been elucidated. Zeb2 is a zinc finger E homeobox-binding transcription factor and is expressed in a variety of immune cells, but its function in iNKT cell differentiation remains also unknown. Here, we show that Zeb2 is dispensable for development of iNKT cells in the thymus and their ...[more]