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MRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice.

ABSTRACT: We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.

SUBMITTER: Kim JY

PROVIDER: S-EPMC10618158 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice.

Kim Jae-Yong JY Jeon Kyeongseok K Park Sang-In SI Bang Yoo-Jin YJ Park Hyeong-Jun HJ Kwak Hye Won HW Kim Do-Hyung DH Lee Soo-Yeon SY Choi Eun-Jin EJ Cho Nam-Hyuk NH Nam Jae-Hwan JH

NPJ vaccines 20231031 1

We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate. ...[more]

PMID: 37907507

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