Ontology highlight
ABSTRACT:
SUBMITTER: Ibtehaz N
PROVIDER: S-EPMC10618451 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Ibtehaz Nabil N Kagaya Yuki Y Kihara Daisuke D
Communications biology 20231031 1
Domains are functional and structural units of proteins that govern various biological functions performed by the proteins. Therefore, the characterization of domains in a protein can serve as a proper functional representation of proteins. Here, we employ a self-supervised protocol to derive functionally consistent representations for domains by learning domain-Gene Ontology (GO) co-occurrences and associations. The domain embeddings we constructed turned out to be effective in performing actua ...[more]