Dataset Information

Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.

ABSTRACT:

Importance

Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) are important complications of surgical procedures for which prevention remains suboptimal. Contemporary data on the incidence of and etiologic factors for these infections are needed to support the development of improved preventive strategies.

Objectives

To assess the occurrence of postoperative S aureus SSIs and BSIs and quantify its association with patient-related and contextual factors.

Design, setting, and participants

This multicenter cohort study assessed surgical patients at 33 hospitals in 10 European countries who were recruited between December 16, 2016, and September 30, 2019 (follow-up through December 30, 2019). Enrolled patients were actively followed up for up to 90 days after surgery to assess the occurrence of S aureus SSIs and BSIs. Data analysis was performed between November 20, 2020, and April 21, 2022. All patients were 18 years or older and had undergone 11 different types of surgical procedures. They were screened for S aureus colonization in the nose, throat, and perineum within 30 days before surgery (source population). Both S aureus carriers and noncarriers were subsequently enrolled in a 2:1 ratio.

Exposure

Preoperative S aureus colonization.

Main outcomes and measures

The main outcome was cumulative incidence of S aureus SSIs and BSIs estimated for the source population, using weighted incidence calculation. The independent association of candidate variables was estimated using multivariable Cox proportional hazards regression models.

Results

In total, 5004 patients (median [IQR] age, 66 [56-72] years; 2510 [50.2%] female) were enrolled in the study cohort; 3369 (67.3%) were S aureus carriers. One hundred patients developed S aureus SSIs or BSIs within 90 days after surgery. The weighted cumulative incidence of S aureus SSIs or BSIs was 2.55% (95% CI, 2.05%-3.12%) for carriers and 0.52% (95% CI, 0.22%-0.91%) for noncarriers. Preoperative S aureus colonization (adjusted hazard ratio [AHR], 4.38; 95% CI, 2.19-8.76), having nonremovable implants (AHR, 2.00; 95% CI, 1.15-3.49), undergoing mastectomy (AHR, 5.13; 95% CI, 1.87-14.08) or neurosurgery (AHR, 2.47; 95% CI, 1.09-5.61) (compared with orthopedic surgery), and body mass index (AHR, 1.05; 95% CI, 1.01-1.08 per unit increase) were independently associated with S aureus SSIs and BSIs.

Conclusions and relevance

In this cohort study of surgical patients, S aureus carriage was associated with an increased risk of developing S aureus SSIs and BSIs. Both modifiable and nonmodifiable etiologic factors were associated with this risk and should be addressed in those at increased S aureus SSI and BSI risk.

SUBMITTER: Troeman DPR

PROVIDER: S-EPMC10618839 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Publications

Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.

Troeman Darren P R DPR Hazard Derek D Timbermont Leen L Malhotra-Kumar Surbhi S van Werkhoven Cornelis H CH Wolkewitz Martin M Ruzin Alexey A Goossens Herman H Bonten Marc J M MJM Harbarth Stephan S Sifakis Frangiscos F Kluytmans Jan A J W JAJW Vlaeminck Jelle J Vilken Tuba T Xavier Basil Britto BB Lammens Christine C van Esschoten Marjolein M Paling Fleur P FP Recanatini Claudia C Coenjaerts Frank F Sellman Bret B Tkaczyk Christine C Weber Susanne S Ekkelenkamp Miquel Bart MB van der Laan Lijckle L Vierhout Bastiaan P BP Couvé-Deacon Elodie E David Miruna M Chadwick David D Llewelyn Martin J MJ Ustianowski Andrew A Bateman Antony A Mawer Damian D Carevic Biljana B Konstantinovic Sonja S Djordjevic Zorana Z Del Toro-López María Dolores MD Gallego Juan Pablo Horcajada JPH Escudero Dolores D Rojo Miquel Pujol MP Torre-Cisneros Julian J Castelli Francesco F Nardi Giuseppe G Barbadoro Pamela P Altmets Mait M Mitt Piret P Todor Adrian A Bubenek-Turconi Serban-Ion SI Corneci Dan D Sandesc Dorel D Gheorghita Valeriu V Brat Radim R Hanke Ivo I Neumann Jan J Tomáš Tomáš T Laffut Wim W Van den Abeele Anne-Marie AM

JAMA network open 20231002 10

<h4>Importance</h4>Staphylococcus aureus surgical site infections (SSIs) and bloodstream infections (BSIs) are important complications of surgical procedures for which prevention remains suboptimal. Contemporary data on the incidence of and etiologic factors for these infections are needed to support the development of improved preventive strategies.<h4>Objectives</h4>To assess the occurrence of postoperative S aureus SSIs and BSIs and quantify its association with patient-related and contextual ...[more]

PMID: 37906196

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Project description:Staphylococcus aureus (S. aureus) infections are important because of their increasing frequency, resistance to antibiotics, and high associated rates of disabilities and deaths. We examined the incidence and correlates of S. aureus infections following 219,958 major surgical procedures in a 5% random sample of fee-for-service Medicare beneficiaries from 2004-2007. Of these surgical patients, 0.3% had S. aureus infections during the hospitalizations when index surgical procedures were performed; and 1.7% and 2.3%, respectively, were hospitalized with infections within 60 days or 180 days following admissions for index surgeries. S. aureus infections occurred within 180 days in 1.9% of patients following coronary artery bypass graft surgery, 2.3% following hip surgery, and 5.9% following gastric or esophageal surgery. Of patients first hospitalized with any major infection reported during the first 180 days after index surgery, 15% of infections were due to S. aureus, 18% to other documented organisms, and no specific organism was reported on claim forms in 67%. Patient-level predictors of S. aureus infections included transfer from skilled nursing facilities or chronic hospitals and comorbid conditions (e.g., diabetes, congestive heart failure, chronic obstructive pulmonary disease, and chronic renal disease). In a logarithmic regression, elective index admissions with S. aureus infection stayed 130% longer than comparable patients without that infection. Within 180 days of the index surgery, 23.9% of patients with S. aureus infection and 10.6% of patients without this infection had died. In a multivariate logistic regression of death within 180 days of admission for the index surgery with adjustment for demographics, co-morbidities, and other risks, S. aureus was associated with a 42% excess risk of death. Due to incomplete documentation of organisms in Medicare claims, these statistics may underestimate the magnitude of S. aureus infection. Nevertheless, this study generated a higher rate of S. aureus infections than previous studies.

Project description:BackgroundDialysis patients are frequently exposed to Staphylococcus aureus due to stays in dialysis centers, hospitals or rest homes. The hemodialysis vascular access is a potential entry site for S. aureus, in particular when using a central venous catheter (CVC) which increases the risk of sepsis compared to arteriovenous (AV) fistula. We prospectively followed a cohort of 86 hemodialysis patients from an outpatient dialysis center over 25 months analyzing S. aureus carrier status, S. aureus infection rates and mortality.MethodsDemographic data and patients´ medical histories were collected and followed from all hemodialysis patients. Blood samples, nasal swabs and swabs from the hemodialysis vascular access site were taken every six months for a period of 25 months and tested for S. aureus. Strains were cultured and further characterized by spa PCR and microarray-based genotyping. Resulting data were compared with those from the general population.ResultsIn cross-sectional analyses, an average of 40% of hemodialysis patients were S. aureus carriers compared to 27% in the general population. Longitudinally, a total of 65% were S. aureus carriers: 16% were persistent carriers, 43% were intermittently colonized. The most common S. aureus lineage in the dialysis patient cohort was the clonal complex (CC) 8 and the spa type t008, while in the general population, the clonal complex CC30 dominates. During the study period, we observed six S. aureus-associated blood stream infections with one S. aureus attributable death. S. aureus carriers with an AV fistula were more densely colonized in the nasal mucosa compared to patients with a CVC. Overall mortality was lower for hemodialysis patients with a positive S. aureus carrier status compared to non-carriers (hazard ratio of 0.19).ConclusionsCompared to the general population, hemodialysis patients were more frequently colonized with S. aureus and displayed both different S. aureus colonization densities as well as lineages, possibly explained by more frequent exposure to health care environments. The lower overall mortality in carriers compared to non-carriers is intriguing and will be investigated in detail in the future.Trial registrationISRCTN 14385893 , 2. October 2018, retrospectively registered.

Dataset Information

Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.

Importance

Objectives

Design, setting, and participants

Exposure

Main outcomes and measures

Results

Conclusions and relevance

Publications

Postoperative Staphylococcus aureus Infections in Patients With and Without Preoperative Colonization.

Similar Datasets

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