Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC10620205 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Li Zhijian Z Amaya Laura L Pi Ruoxi R Wang Sean K SK Ranjan Alok A Waymouth Robert M RM Blish Catherine A CA Chang Howard Y HY Wender Paul A PA
Nature communications 20231101 1
The introduction of more effective and selective mRNA delivery systems is required for the advancement of many emerging biomedical technologies including the development of prophylactic and therapeutic vaccines, immunotherapies for cancer and strategies for genome editing. While polymers and oligomers have served as promising mRNA delivery systems, their efficacy in hard-to-transfect cells such as primary T lymphocytes is often limited as is their cell and organ tropism. To address these problem ...[more]