Impact of periodontitis on circulating cell-free DNA levels as a measure of cardiovascular disease.

ABSTRACT:

Objectives

The present study aims to assess the serum circulating cell-free (cfDNA) concentrations in patients with periodontitis and cardiovascular disease (CVD) and to evaluate the impact of periodontitis on circulating cfDNA levels and the confounding factors that might mediated the possible relationship.

Materials and methods

Healthy controls (n=30) and patients with CVD (n=31), periodontitis (n=31), and periodontitis + CVD (n=30) were enrolled in the present study. All subjects underwent regular periodontal examination and blood sampling and cfDNA evaluation. The analysis of the plasma cfDNA concentrations was performed using a dsDNA Assay Kit.

Results

In comparison with healthy controls and CVD patients, periodontitis and periodontitis+CVD exhibited significantl

SUBMITTER: Isola G 

PROVIDER: S-EPMC10630221 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature