Evaluation and mechanism study of Pien Tze Huang against EV-A71 infection.
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SUBMITTER: Wang H
PROVIDER: S-EPMC10637388 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
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Evaluation and mechanism study of Pien Tze Huang against EV-A71 infection.
Wang Huiqiang H Chen Fenbei F Wang Shicong S Li Yuhuan Y Liu Ting T Li Yinghong Y Deng Hongbin H Dong Jingwen J Pang Jing J Song Danqing D Zhang Dousheng D Yu Juan J Wang Yanxiang Y
Frontiers in pharmacology 20231026
Hand, foot, and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) infection, currently lacks specific preventive and therapeutic interventions. Here, we demonstrated that Pien Tze Huang (PZH) could dose-dependently inhibit EV-A71 replication at the cellular level, resulting in significant reductions in EV-A71 virus protein 1 (VP1) expression and viral yields in Vero and human rhabdomyosarcoma cells. More importantly, we confirmed that PZH could protect mice from EV-A71 infection for the fi ...[more]
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